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As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging
Both medications are weekly injections that work on the hormones tied to hunger, metabolism, and blood sugar
Unfortunately, like other GLP1R agonists, retatrutide also produced significant GI side effects in a large proportion of participants (35% in the 36 week study and 45% in the 48 week study at the 12 mg dose) (Rosenstock et al., 2023)
Common side effects include: Nausea Vomiting Diarrhea Constipation Bloating Stomach discomfort Indigestion These side effects are typically most noticeable when treatment begins or when doses are increased
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